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    سارس


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    (Wikipedia) - Severe acute respiratory syndrome   (Redirected from SARS) "SARS" redirects here. For other uses, see SARS (disambiguation). This article is about the 2002–2003 originated syndrome, centered on Hong Kong. For the 2012–2013 originated syndrome, centered on Saudi Arabia, see Middle East respiratory syndrome coronavirus. Severe Acute Respiratory Syndrome (SARS) ICD-10 ICD-9 DiseasesDB MedlinePlus eMedicine Patient UK MeSH
    Classification and external resources
    SARS coronavirus (SARS-CoV) is causative of the syndrome.
    U04
    079.82
    32835
    007192
    med/3662
    Severe acute respiratory syndrome
    D045169

    Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the SARS coronavirus (SARS-CoV). Between November 2002 and July 2003, an outbreak of SARS in southern China caused an eventual 8,273 cases and 775 deaths reported in multiple countries with the majority of cases in Hong Kong (9.6% fatality rate) according to the World Health Organization (WHO). Within weeks, SARS spread from Hong Kong to infect individuals in 37 countries in early 2003.

    Contents

    Signs and symptoms

    Initial symptoms are flu-like and may include fever, myalgia, lethargy symptoms, cough, sore throat, and other nonspecific symptoms. The only symptom common to all patients appears to be a fever above 38 °C (100 °F). Shortness of breath may occur later. The patient has symptoms as with a cold in the first stage, but later on they resemble influenza. SARS may occasionally lead to pneumonia, either direct viral pneumonia or secondary bacterial pneumonia.

    DiagnosisA chest X-ray showing increased opacity in both lungs, indicative of pneumonia, in a patient with SARS

    SARS may be suspected in a patient who has:

  • Contact (sexual or casual, including tattoos) with someone with a diagnosis of SARS within the last 10 days OR
  • Travel to any of the regions identified by the World Health Organization (WHO) as areas with recent local transmission of SARS (affected regions as of 10 May 2003 were parts of China, Hong Kong, Singapore and the town of Geraldton, Ontario, Canada).
  • A probable case of SARS has the above findings plus positive chest X-ray findings of atypical pneumonia or respiratory distress syndrome.

    The World Health Organization (WHO) has added the category of "laboratory confirmed SARS" for patients who would otherwise fit the above "probable" category who do not (yet) have the chest X-ray changes, but do have positive laboratory diagnosis of SARS based on one of the approved tests (ELISA, immunofluorescence or PCR).

    The chest X-ray (CXR) appearance of SARS is variable. There is no pathognomonic appearance of SARS, but is commonly felt to be abnormal with patchy infiltrates in any part of the lungs. The initial CXR may be clear.

    Treatment

    Antibiotics are ineffective, as SARS is a viral disease. Treatment of SARS is largely supportive with antipyretics, supplemental oxygen and mechanical ventilation as needed.

    Suspected cases of SARS must be isolated, preferably in negative pressure rooms, with complete barrier nursing precautions taken for any necessary contact with these patients.

    Some of the more serious damage in SARS may be due to the body''s own immune system reacting in what is known as cytokine storm.

    As of 2013, there is no cure or protective vaccine for SARS that is safe for use in humans. The identification and development of novel vaccines and medicines to treat SARS is a priority for governments and public health agencies around the world. MassBiologics, a non-profit organization engaged in the discovery, development and manufacturing of biologic therapies, is cooperating with researchers at NIH and the CDC developed a monoclonal antibody therapy that demonstrated efficacy in animal models.

    Prognosis

    Several consequent reports from China on some recovered SARS patients showed severe long-time sequelae exist. The most typical diseases include, among other things, pulmonary fibrosis, osteoporosis, and femoral necrosis, which have led to the complete loss of working ability or even self-care ability of these cases. As a result, some of the post-SARS patients suffer from major depressive disorder.

    Prevention

    There is no vaccine to date. Isolation and quarantine remain the most effective means to prevent the spread of SARS. In addition, handwashing, use of universal precautions, disinfection of surfaces for fomites, and use of a surgical mask are recommended. Avoid contact with bodily fluids. Continue with precautions for at least 10 days after the person''s signs and symptoms have disappeared. Keep children home from school if they develop a fever or respiratory symptoms within 10 days of being exposed to someone with SARS. Wash personal items in hot, soapy water including the eating utensils and dishes, bedding and clothing of someone with SARS. Annual influenza vaccinations and 5-year pneumococcal vaccinations may be beneficial; but vaccinations only reduce or weaken the severity of SARS infection.

    EpidemiologyAreas of the World Affected by SARS in 2002 – 2003

    SARS is still considered a relatively rare disease, with 8,273 cases as of 2003.

    History
    Probable cases of SARS by country, 1 November 2002 – 31 July 2003.
    Country or Region Cases Deaths SARS cases dead due to other causes Fatality (%)
    China * 5,328 349 19 6.6
    Hong Kong * 1,755 299 5 17
    Canada 251 44 0 18
    Taiwan ** 346 37 36 11
    Singapore 238 33 0 14
    Vietnam 63 5 0 8
    United States 27 0 0 0
    Philippines 14 2 0 14
    Mongolia 9 0 0 0
    Macau * 1 0 0 0
    Kuwait 1 0 0 0
    Republic of Ireland 1 0 0 0
    Romania 1 0 0 0
    Russian Federation 1 0 0 0
    Spain 1 0 0 0
    Switzerland 1 0 0 0
    South Korea 4 0 0 0
    Total 8273 775 60 9.6
    (*) Figures for the People''s Republic of China exclude the Special Administrative Regions (Macau SAR, Hong Kong SAR), which are reported separately by the WHO.
    (**) Since 11 July 2003, 325 Taiwanese cases have been ''discarded''. Laboratory information was insufficient or incomplete for 135 discarded cases; 101 of these patients died.
    Source:WHO.
    Outbreak in south China Main article: Progress of the SARS outbreak

    The epidemic of SARS appears to have started in Guangdong Province, China in November 2002. The first reported case of SARS originated in Shunde, Foshan, Guangdong in November 2002, and the patient, a farmer, was treated in the First People''s Hospital of Foshan (Mckay Dennis). The patient died soon after, and no definite diagnosis was made on his cause of death. Despite taking some action to control it, Chinese government officials did not inform the World Health Organization of the outbreak until February 2003. This lack of openness caused delays in efforts to control the epidemic, resulting in criticism of the People''s Republic of China from the international community. China has since officially apologized for early slowness in dealing with the SARS epidemic.

    The first clue of the outbreak appears to be 27 November 2002 when Canada''s Global Public Health Intelligence Network (GPHIN), an electronic warning system that is part of the World Health Organization''s Global Outbreak and Alert Response Network (GOARN), picked up reports of a "flu outbreak" in China through Internet media monitoring and analysis and sent them to the WHO. Importantly, while GPHIN''s capability had recently been upgraded to enable Arabic, Chinese, English, French, Russian, and Spanish translation, the system was limited to English or French in presenting this information. Thus, while the first reports of an unusual outbreak were in Chinese, an English report was not generated until 21 January 2003.

    Subsequent to this, the WHO requested information from Chinese authorities on 5 and 11 December. Despite the successes of the network in previous outbreak of diseases, it was proven rather defective after receiving intelligence on the media reports from China several months after the outbreak of SARS. Along with the second alert, WHO released the name, definition, as well as an activation of a coordinated global outbreak response network that brought sensitive attention and containment procedures (Heymann, 2003). However, by then although the new definitions do give nations a guideline to contain SARS, over 500 deaths and an additional 2,000 cases had already occurred worldwide.

    In early April, after Jiang Yanyong pushed to report the danger to China, there appeared to be a change in official policy when SARS began to receive a much greater prominence in the official media. Some have directly attributed this to the death of American James Earl Salisbury. However, also in early April, accusations by Jiang Yanyong emerged regarding the undercounting of cases in Beijing military hospitals. After intense pressure, Chinese officials allowed international officials to investigate the situation there. This revealed problems plaguing the aging mainland Chinese healthcare system, including increasing decentralization, red tape, and inadequate communication.

    Many doctors and other medical staff in many nations heroically risked their lives treating patients and containing the infection before ways to prevent infection were known. Not all survived.

    Spread to other countries and regions

    The epidemic reached the public spotlight in February 2003, when an American businessman traveling from China became afflicted with pneumonia-like symptoms while on a flight to Singapore. The plane stopped at Hanoi, Vietnam, where the victim died in The French Hospital of Hanoi. Several of the medical staff who treated him soon developed the same disease despite basic hospital procedures. Italian doctor Carlo Urbani identified the threat and communicated it to WHO and the Vietnamese government; he later succumbed to the disease.

    The severity of the symptoms and the infection of hospital staff alarmed global health authorities fearful of another emergent pneumonia epidemic. On 12 March 2003, the WHO issued a global alert, followed by a health alert by the United States Centers for Disease Control and Prevention (CDC). Local transmission of SARS took place in Toronto, Ottawa, San Francisco, Ulan Bator, Manila, Singapore, Taiwan, Hanoi and Hong Kong whereas within China it spread to Guangdong, Jilin, Hebei, Hubei, Shaanxi, Jiangsu, Shanxi, Tianjin, and Inner Mongolia.

    9th floor layout of the Hotel Metropole in Hong Kong, showing where superspreading event of severe acute respiratory syndrome (SARS) occurred

    In Hong Kong, the first cohort of affected people were discharged from the hospital on 29 March 2003. The disease spread in Hong Kong from a mainland doctor who arrived in February and stayed at the ninth floor of the Metropole Hotel in Kowloon, infecting 16 of the hotel visitors. Those visitors traveled to Canada, Singapore, Taiwan, and Vietnam, spreading SARS to those locations.

    Another larger cluster of cases in Hong Kong centred on the Amoy Gardens housing estate. Its spread is suspected to have been facilitated by defects in its drainage system. Concerned citizens in Hong Kong worried that information was not reaching people quickly enough and created a website called sosick.org, which eventually forced the Hong Kong government to provide information related to SARS in a timely manner.

    Identification of virus

    The CDC and a Canadian laboratory identified the SARS genome in April, 2003. Scientists at Erasmus University in Rotterdam, the Netherlands demonstrated that the SARS coronavirus fulfilled Koch''s postulates thereby confirming it as the causative agent. In the experiments, macaques infected with the virus developed the same symptoms as human SARS victims.

    In late May 2003, studies from samples of wild animals sold as food in the local market in Guangdong, China, found the SARS coronavirus could be isolated from masked palm civets (Paguma sp.), but the animals did not always show clinical signs. The preliminary conclusion was the SARS virus crossed the xenographic barrier from palm civet to humans, and more than 10,000 masked palm civets were killed in Guangdong Province. Virus was also later found in raccoon dogs (Nyctereuteus sp.), ferret badgers (Melogale spp.), and domestic cats. In 2005, two studies identified a number of SARS-like coronaviruses in Chinese bats.

    Phylogenetic analysis of these viruses indicated a high probability that SARS coronavirus originated in bats and spread to humans either directly or through animals held in Chinese markets. The bats did not show any visible signs of disease, but are the likely natural reservoirs of SARS-like coronaviruses. In late 2006, scientists from the Chinese Centre for Disease Control and Prevention of Hong Kong University and the Guangzhou Centre for Disease Control and Prevention established a genetic link between the SARS coronavirus appearing in civets and humans, bearing out claims that the disease had jumped across species.

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