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    * Camphor *

    کافور


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    (Wikipedia) - Camphor For other uses, see Camphor (disambiguation). Camphor Identifiers Properties Hazards Related compounds
    IUPAC name

    1,7,7-Trimethylbicycloheptan-2-one

    Systematic name

    1,7,7-Trimethylbicycloheptan-2-one

    Other names

    2-Bornanone; Bornan-2-one; 2-Camphanone; Formosa

    CAS number 76-22-2 Y, 21368-68-3 Y, 464-49-3 (R) Y, 464-48-2 (S) Y
    PubChem 2537, 9543187 (R), 10050 (S)
    ChemSpider 2441 Y, 7822160 (R) Y, 9655 (S) Y
    UNII 5TJD82A1ET Y
    EC number 200-945-0
    UN number 2717
    DrugBank DB01744
    KEGG D00098 Y
    MeSH Camphor
    ChEBI CHEBI:36773 Y
    ChEMBL CHEMBL504760 N
    IUPHAR ligand 2422
    RTECS number EX1225000
    ATC code C01EB02
    Beilstein Reference 1907611
    Gmelin Reference 83275
    3DMet B04729
    Jmol-3D images Image 1 Image 2
    SMILES
    • CC1(C)C2CCC1(C)C(=O)C2

      O=C1CC2CCC1(C)C2(C)C

    InChI
    • InChI=1S/C10H16O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7H,4-6H2,1-3H3 Y Key: DSSYKIVIOFKYAU-UHFFFAOYSA-N Y

      InChI=1/C10H16O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7H,4-6H2,1-3H3 Key: DSSYKIVIOFKYAU-UHFFFAOYAK

    Molecular formula C10H16O
    Molar mass 152.23 g mol−1
    Appearance White, translucent crystals
    Density 0.990 g cm−3
    Melting point 175 to 177 °C (347 to 351 °F; 448 to 450 K)
    Boiling point 204 °C (399 °F; 477 K)
    Solubility in water 1.2 g dm−3
    Solubility in acetone ~2500 g dm−3
    Solubility in acetic acid ~2000 g dm−3
    Solubility in diethyl ether ~2000 g dm−3
    Solubility in chloroform ~1000 g dm−3
    Solubility in ethanol ~1000 g dm−3
    log P 2.089
    Vapor pressure 4 mmHg (at 70 °C)
    Chiral rotation D +44.1°
    EU classification F Xn
    R-phrases R11 R22 R36/37/38
    S-phrases S16 S26
    NFPA 704 2 2 0
    Flash point 54 °C (129 °F; 327 K)
    Explosive limits 3.5%
    Related Ketones Fenchone, Thujone
    Related compounds Camphene, Pinene, Borneol, Isoborneol, Camphorsulfonic acid
    Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
     N (verify) (what is: Y/N?)
    Infobox references

    Camphor /ˈkæmfər/ is a waxy, flammable, white or transparent solid with a strong aromatic odor. It is a terpenoid with the chemical formula C10H16O. It is found in Zam-Buk, the wood of the camphor laurel (Cinnamomum camphora), a large evergreen tree found in Asia (particularly in Sumatra, Borneo and Taiwan) and also of Dryobalanops aromatica, a giant of the Bornean forests. It also occurs in some other related trees in the laurel family, notably Ocotea usambarensis. Dried rosemary leaves (Rosmarinus officinalis), in the mint family, contain up to 20% camphor. It can also be synthetically produced from oil of turpentine. It is used for its scent, as an ingredient in cooking (mainly in India), as an embalming fluid, for medicinal purposes, and in religious ceremonies. A major source of camphor in Asia is camphor basil.

    Norcamphor is a camphor derivative with the three methyl groups replaced by hydrogen.

    Contents

    History

    The word camphor derives from the French word camphre, itself from Medieval Latin camfora, from Arabic kafur, from Sanskrit, karpūra. The term ultimately was derived from Old Malay kapur barus which means "the chalk of Barus". Barus was the name of an ancient port located near modern Sibolga city on the western coast of Sumatra island (today North Sumatra Province, Indonesia). This port was initially built prior to the Indian - Batak trade in camphor and spices. Traders from India, East Asia and the Middle East would use the term kapur barus to buy the dried extracted ooze of camphor trees from local Batak tribesmen; in proto Malay-Austronesian language (Sanskrit adapted-Bataknese alphabets), it is also known as kapur Barus. Even now, the local tribespeople and Indonesians in general refer to naphthalene balls and moth balls as kapur Barus. For the local tribespeople, the use of camphor ranges from deodorant, wood-finishing veneer, traditional rituals and non-edible preservatives as the camphor tree itself is natively found in that region.

    A sample of sublimed camphor

    The sublimating capability of camphor gives it several uses. An early international trade in it made camphor widely known throughout Arabia in pre-Islamic times, as it is mentioned in the Quran 76:5 as a flavoring for drinks. By the 13th century, it was used in recipes everywhere in the Muslim world, ranging from main dishes such as tharid and stew to desserts.

    Already in the 19th century, it was known that with nitric acid, camphor could be oxidized into camphoric acid. Haller and Blanc published a semisynthesis of camphor from camphoric acid, which, although demonstrating its structure, would not prove it. The first complete total synthesis for camphoric acid was published by Gustaf Komppa in 1903. Its starting materials were diethyl oxalate and 3,3-dimethylpentanoic acid, which reacted by Claisen condensation to give diketocamphoric acid. Methylation with methyl iodide and a complicated reduction procedure produced camphoric acid. William Perkin published another synthesis a short time later. Previously, some organic compounds (such as urea) had been synthesized in the laboratory as a proof of concept, but camphor was a scarce natural product with a worldwide demand. Komppa realized this and began industrial production of camphor in Tainionkoski, Finland, in 1907.

    Production

    Camphor can be produced from alpha-pinene, which is abundant in the oils of coniferous trees and can be distilled from turpentine produced as a side product of chemical pulping. With acetic acid as the solvent and with catalysis by a strong acid, alpha-pinene readily rearranges into camphene, which in turn undergoes Wagner-Meerwein rearrangement into the isobornyl cation, which is captured by acetate to give isobornyl acetate. Hydrolysis into isoborneol followed by oxidation gives racemic camphor. By contrast, camphor occurs naturally as D-camphor, the (R)-enantiomer.

    Biosynthesis

    In biosynthesis, camphor is produced from geranyl pyrophosphate, via cyclisation of linaloyl pyrophosphate to bornyl pyrophosphate, followed by hydrolysis to borneol and oxidation to camphor.

    Reactions

    Typical camphor reactions are

    Camphor can also be reduced to isoborneol using sodium borohydride.

    In 1998, K. Chakrabarti and coworkers from the Indian Association for the Cultivation of Science, Kolkata, prepared diamond thin film using camphor as the precursor for chemical vapor deposition.

    In 2007, carbon nanotubes were successfully synthesized using camphor in chemical vapor deposition process.

    Uses

    Modern uses include camphor as a plasticizer for nitrocellulose (see Celluloid), as a moth repellent, as an antimicrobial substance, in embalming, and in fireworks. Solid camphor releases fumes that form a rust-preventative coating, and is therefore stored in tool chests to protect tools against rust.

    Some folk remedies state camphor will deter snakes and other reptiles due to its strong odor. Similarly, camphor is believed to be toxic to insects and is thus sometimes used as a repellent. Camphor crystals are sometimes used to prevent damage to insect collections by other small insects. They are also used as a cough suppressant.

    Culinary

    In ancient and medieval Europe, camphor was used as an ingredient in sweets. It was used in a wide variety of both savory and sweet dishes in medieval Arabic language cookbooks, such as al-Kitab al-Ṭabikh compiled by ibn Sayyâr al-Warrâq in the 10th century, and an anonymous Andalusian cookbook of the 13th century. It also appears in sweet and savory dishes in a book written in the late 15th century for the sultans of Mandu, the Ni''matnama.

    Currently, camphor is used as a flavoring, mostly for sweets, in Asia. It is widely used in cooking, mainly for dessert dishes, in India where it is known as kachha karpooram or "pachha karpoora" ("crude/raw camphor"), in (Telugu:పచ్చ కర్పూర), (Tamil:பச்சைக் கற்பூரம்), (Kannada:ಪಚ್ಚ ಕರ್ಪೂರ), and is available in Indian grocery stores where it is labeled as "edible camphor". Flavored tablets of camphor are also used as an anti-odor element and kept in clothes used on special occasions and festivals, and also in cupboard corners as a cockroach repellent.

    Medicinal

    Camphor is readily absorbed through the skin and produces a feeling of cooling similar to that of menthol, and acts as slight local anesthetic and antimicrobial substance. There are anti-itch gels and cooling gels with camphor as the active ingredient. Camphor is an active ingredient (along with menthol) in vapor-steam products, such as Vicks VapoRub.

    Camphor may also be administered orally in small quantities (50 mg) for minor heart symptoms and fatigue. Through much of the 1900s this was sold under the trade name Musterole; production ceased in the 1990s.

    Camphor was used in ancient Sumatra to treat sprains, swellings, and inflammation. Camphor is a component of paregoric, an opium/camphor tincture from the 18th century. Also in the 18th century, camphor was used by Auenbrugger in the treatment of mania. Based on Hahnemann''s writings, camphor (dissolved in alcohol) was also successfully used to treat the 1854-1855 cholera epidemics in Naples.

    Camphor was the original compound used in the development of convulsive therapies for psychiatric illness. It was quite successful, but was supplanted by other chemicals and later electricity as the inducing agent.

    Herbalism

    Camphor is available as a decongestant and as an essential oil for aromatherapy or topical application.

    Hindu religious ceremonies

    Camphor is widely used in Hindu religious ceremonies. Hindus worship a holy flame by burning camphor, which forms an important part of many religious ceremonies. Camphor is used in the Mahashivratri celebrations of Shiva, the Hindu god of destruction and (re)creation. As a natural pitch substance, it burns cool without leaving an ash residue, which symbolizes consciousness. Most temples in southern India have stopped lighting camphor in the main Sanctum Sanctorum because of the heavy carbon deposits it produces; however, open areas still burn it.

    In Gujarat, Tamil Nadu, Andhra Pradesh, Madhya Pradesh, Maharashtra, Karnataka, Kerala & Andamans, camphor is the primary ingredient in any holy rituals. At the end of a holy ritual camphor flame (called Aarti) is burned for the deities.

    In Hindu pujas ceremonies, camphor is burned in a ceremonial spoon for performing aarti. This type of camphor, the processed white crystalline kind, is also sold at Indian grocery stores. It is not suitable for cooking and is hazardous to health if eaten.

    Effects on the body Small dose

    Its effects on the body include tachycardia, vasodilation in skin (flushing), slower breathing, reduced appetite, increased secretions and excretions such as perspiration, diuretic. Therefore camphor must be used carefully and in low dosage in baby oil, where it is used for its calming effects.

    Large dose toxicity

    Camphor is poisonous in large doses. It produces symptoms of irritability, disorientation, lethargy, muscle spasms, vomiting, abdominal cramps, convulsions, and seizures. Lethal doses in adults are in the range 50–500 mg/kg (orally). Generally, two grams cause serious toxicity and four grams are potentially lethal.

    Regulation

    In 1980, the U.S. Food and Drug Administration set a limit of 11% allowable camphor in consumer products, and totally banned products labeled as camphorated oil, camphor oil, camphor liniment, and camphorated liniment (except "white camphor essential oil", which contains no significant amount of camphor). Since alternative treatments exist, medicinal use of camphor is discouraged by the FDA, except for skin-related uses, such as medicated powders, which contain only small amounts of camphor.

    Tags:Arabia, Arabic, Asia, Camphor, EU, Europe, Finland, French, India, Indonesia, Islamic, Kolkata, Middle East, Muslim, Quran, Sanskrit, Science, Taiwan, Wikipedia


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